Dosage of memantine

The daily dose of memantine is 20 mg per day.

This dose is achieved by upward titration 5 mg per week over the first 3 weeks as follows: Treatment should be started with 5 mg daily (half a tablet in the morning) during the 1st week. In the 2nd week 10 mg per day (half a tablet twice a day) and in the 3rd week 15 mg per day is recommended (one tablet in the morning and half a tablet in the afternoon). From the 4th week on, treatment can be continued with the recommended maintenance dose of 20 mg per day (one tablet twice a day).

Renal impairment: In patients with normal to mildly impaired renal function (serum creatinine levels of up to 130 µmol/l) no dose reduction is needed. In patients with moderate renal impairment (creatinine clearance 40-60 ml/ min/ 1.73 m²) daily dose should be reduced to 10 mg per day. No data is available for patients with severely reduced kidney function.